Madonna has cancelled the first night of her 15-date residency at the London Palladium.
The concert was due to take place on Monday 27 January, with a further 14 nights at the same UK venue.
Fans received a message announcing that refunds for the show have already been issued.
A statement from Madonna in an email sent to fans read: “I am deeply sorry that I have to cancel my concert scheduled for Monday January 27 in London. Under doctors guidance I have been told to rest for a few days.
“As you all know I have injuries that have plagued me since the beginning of the tour but I must always listen to my body and put my health first.”
1/40 1984
Rex
2/40 1984
Madonna on ‘Saturday Show’, TV Programme
Rex
3/40 1980s
Madonna performing in the 80s
Rex
4/40 1985
Madonna in ‘Desperately Seeking Susan’
Rex
5/40 1985
Madonna – Material Girl music video
Sire/Warner Bros. Records
6/40 1986
Madonna and Sean Penn in ‘Shanghai Surprise’
Rex
7/40 1986
Madonna – Papa Don’t Preach music video
Sire/Warner Bros. Records
8/40 1987
Madonna performing at Wembley Stadium
Rex
9/40 1987
Griffin Dunne and Madonna in ‘Who’s That Girl’
Rex
10/40 1987
Fans wait for the arrival of Madonna at Heathrow Airport
PA
11/40 1987
Madonna performs on stage as part of her ‘Who’s That Girl World Tour’ at Roundhay Park, Leeds
PA
12/40 1988
Rex
13/40 1989
Madonna – Like a Prayer music video
Sire/Warner Bros. Records
14/40 1990
Madonna performing on the Blond Ambition Tour in Tokyo, Japan
Rex
15/40 1990
Madonna strikes a pose in her 1990 video for ‘Vogue’
Sire/Warner Bros. Records
16/40 1990
Madonna opening her Blond Ambition World Tour
Rex
17/40 1992
The Launch of the book ‘Sex’ by Madonna
Rex
18/40 1995
Madonna performs at the Brit Awards
PA
19/40 1995
Madonna is joined by actors Jonathan Pryce and Antonio Banderas in London, as music recording began on the film version of ‘Evita’
PA
20/40 1998
Madonna – Ray of Light music video
Maverick/Warner Bros. Records
21/40 2000
Madonna and Guy Ritchie leave Dornoch Cathedral after having their baby Rocco Christened
PA
22/40 2000
Madonna with the Best Female award at the MTV Europe Music Awards held at the Globe Arena in Stockholm
PA
23/40 2000
Madonna and British film director Guy Ritchie at the Evening Standard British Film Awards, held at the Savoy Hotel in London
PA
24/40 2000
Madonna with her MTV Award for Best Female Artist, during the MTV Awards ceremony at the Filaforum near Milan
PA
25/40 2001
Madonna celebrates American Independence Day by kicking off the UK leg of her Drowned World tour with a spectacular show at Earl’s Court in west London
PA
26/40 2002
Queen Elizabeth II meets Madonna at the World premiere of “Die another Day”, at the Royal Albert Hall
PA
27/40 2003
Britney Spears kissing Madonna at the MTV video music awards in New York
Frank Micelotta/Getty
28/40 2003
Madonna at the launch of her first children’s book The English Roses held at the Kensington Roof Gardens, London
PA
29/40 2004
Madonna performs during the London leg of her ‘re-Invention’ world tour
PA
30/40 2005
Madonna appears backstage at the MTV Europe Music Awards in Lisbon
PA
31/40 2005
Madonna performing at G.A.Y in London to launch her new album ‘Confessions On A Dancefloor’
PA
32/40 2005
Madonna – Hung Up video
Warner Bros. Records
33/40 2006
Madonna collects her award for Best International Female, on stage at the Brit Awards 2006
PA
34/40 2008
Madonna performs during her ‘Sticky and Sweet’ tour at Wembley Stadium
PA
35/40 2008
Madonna performs during her ‘Sticky and Sweet’ tour in Cardiff
PA
36/40 2015
Madonna performs at the 2015 Brit Awards in London
PA
37/40 2016
Madonna and fashion designer Riccardo Tisci attend the “Manus x Machina: Fashion In An Age Of Technology” Costume Institute Gala at Metropolitan Museum of Art in New York City
Getty
38/40 2017
Madonna at the “Rei Kawakubo/Comme des Garcons: Art Of The In-Between” Met Gala
Getty
39/40 2018
Madonna speaks to the press at a news conference in Blantyre, Malawi. She has adopted four Malawian children and was in the country to celebrate the first anniversary of the Mercy James Centre for Pediatric Surgery and Intensive Care, named after one of her adopted daughters
AP
40/40 2018
Madonna and Jean Paul Gaultier arrive for the 2018 Met Gala
AFP/Getty Images
1/40 1984
Rex
2/40 1984
Madonna on ‘Saturday Show’, TV Programme
Rex
3/40 1980s
Madonna performing in the 80s
Rex
4/40 1985
Madonna in ‘Desperately Seeking Susan’
Rex
5/40 1985
Madonna – Material Girl music video
Sire/Warner Bros. Records
6/40 1986
Madonna and Sean Penn in ‘Shanghai Surprise’
Rex
7/40 1986
Madonna – Papa Don’t Preach music video
Sire/Warner Bros. Records
8/40 1987
Madonna performing at Wembley Stadium
Rex
9/40 1987
Griffin Dunne and Madonna in ‘Who’s That Girl’
Rex
10/40 1987
Fans wait for the arrival of Madonna at Heathrow Airport
PA
11/40 1987
Madonna performs on stage as part of her ‘Who’s That Girl World Tour’ at Roundhay Park, Leeds
PA
12/40 1988
Rex
13/40 1989
Madonna – Like a Prayer music video
Sire/Warner Bros. Records
14/40 1990
Madonna performing on the Blond Ambition Tour in Tokyo, Japan
Rex
15/40 1990
Madonna strikes a pose in her 1990 video for ‘Vogue’
Sire/Warner Bros. Records
16/40 1990
Madonna opening her Blond Ambition World Tour
Rex
17/40 1992
The Launch of the book ‘Sex’ by Madonna
Rex
18/40 1995
Madonna performs at the Brit Awards
PA
19/40 1995
Madonna is joined by actors Jonathan Pryce and Antonio Banderas in London, as music recording began on the film version of ‘Evita’
PA
20/40 1998
Madonna – Ray of Light music video
Maverick/Warner Bros. Records
21/40 2000
Madonna and Guy Ritchie leave Dornoch Cathedral after having their baby Rocco Christened
PA
22/40 2000
Madonna with the Best Female award at the MTV Europe Music Awards held at the Globe Arena in Stockholm
PA
23/40 2000
Madonna and British film director Guy Ritchie at the Evening Standard British Film Awards, held at the Savoy Hotel in London
PA
24/40 2000
Madonna with her MTV Award for Best Female Artist, during the MTV Awards ceremony at the Filaforum near Milan
PA
25/40 2001
Madonna celebrates American Independence Day by kicking off the UK leg of her Drowned World tour with a spectacular show at Earl’s Court in west London
PA
26/40 2002
Queen Elizabeth II meets Madonna at the World premiere of “Die another Day”, at the Royal Albert Hall
PA
27/40 2003
Britney Spears kissing Madonna at the MTV video music awards in New York
Frank Micelotta/Getty
28/40 2003
Madonna at the launch of her first children’s book The English Roses held at the Kensington Roof Gardens, London
PA
29/40 2004
Madonna performs during the London leg of her ‘re-Invention’ world tour
PA
30/40 2005
Madonna appears backstage at the MTV Europe Music Awards in Lisbon
PA
31/40 2005
Madonna performing at G.A.Y in London to launch her new album ‘Confessions On A Dancefloor’
PA
32/40 2005
Madonna – Hung Up video
Warner Bros. Records
33/40 2006
Madonna collects her award for Best International Female, on stage at the Brit Awards 2006
PA
34/40 2008
Madonna performs during her ‘Sticky and Sweet’ tour at Wembley Stadium
PA
35/40 2008
Madonna performs during her ‘Sticky and Sweet’ tour in Cardiff
PA
36/40 2015
Madonna performs at the 2015 Brit Awards in London
PA
37/40 2016
Madonna and fashion designer Riccardo Tisci attend the “Manus x Machina: Fashion In An Age Of Technology” Costume Institute Gala at Metropolitan Museum of Art in New York City
Getty
38/40 2017
Madonna at the “Rei Kawakubo/Comme des Garcons: Art Of The In-Between” Met Gala
Getty
39/40 2018
Madonna speaks to the press at a news conference in Blantyre, Malawi. She has adopted four Malawian children and was in the country to celebrate the first anniversary of the Mercy James Centre for Pediatric Surgery and Intensive Care, named after one of her adopted daughters
AP
40/40 2018
Madonna and Jean Paul Gaultier arrive for the 2018 Met Gala
AFP/Getty Images
She continued: “The last thing I want to do is disappoint my fans or compromise the integrity of my show. So I will keep going until I cannot.
“As always – anyone who purchased a ticket will be refunded for tickets purchased that evening.”
The statement added that the show at the London Palladium on Wednesday 29 January will take place as scheduled.
This is the 10th date in Madonna’s sold-out Madame X tour to be cancelled. The star has been suffering from an unspecified injury that she said has been causing her “overwhelming pain”.
In November, she was sued by a fan over claims that she started a concert two hours later than originally billed.
The Independent has contacted Madonna’s representative for comment.